Biotechnology PowerPoint Presentation free download Biology Diagrams Here we show that the genome-wide transcriptional response to heat shock in mammals is rapid and dynamic and results in induction of several hundred and repression of several thousand genes.
Heat shock causes proteotoxic stress that induces various cellular responses, including delayed mitotic progression and the generation of an aberrant number of chromosomes. In this study, heat shock
Heat shock transcription factors demonstrate a distinct mode of ... Biology Diagrams
1. Introduction Heat shock is caused by fever and inflammation in the human body and an increased temperature of the surrounding environment, which induces protein aggregation and misfolding [1]. Heat shock prompts cellular reactions, such as cell death, cell cycle arrest, and protein degradation by eliciting DNA damage response, changing in cell membrane fluidity, and disorganizing of This cytoplasmic protein stress response activates the transcription of heat shock protein (HSP) genes through the action of heat shock transcription factors (HSFs), which are crucial for preserving cellular protein homeostasis [19, 20].
Furthermore, the most famous transcription factor against temperature stress is heat shock transcription factor/heat shock factor (HSF). HSF was discovered as a transcription factor essential for the heat shock response. The heat shock response is a cellular protective mechanism against heat stress that was discovered by Ritossa in 1962.
Cell Cycle Regulation by Heat Shock Transcription Factors Biology Diagrams
Heat shock is a physiological and environmental stress that leads to the denaturation and inactivation of cellular proteins and is used in hyperthermia cancer therapy. Previously, we revealed that mild heat shock (42 ยฐC) delays the mitotic progression by activating the spindle assembly checkpoint (S โฆ
