Remember All Living Things are Made of Cells Biology Diagrams Describe how self-renewal and the cell cycle are regulated in stem cells. Stem Cells and Cell Cycle Regulation Stem cells are characterized by their unlimited ability to self-renew and capability to differentiate into multiple cell lineages [1]. In this end, stem cells undergo an asymmetric cell division during which only one of the two daughter cells differentiates. This is a complex mechanism in which different transcription factors, epigenetic modifications and However, the precise mechanism underlying miRNA-mediated regulation of cell cycle in stem cells is still incompletely understood. In this review, we discuss current knowledge of miRNAs regulatory role in cell cycle progression of stem cells.
In this Review, the authors discuss how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent An overview of cell cycle regulation in ESCs by miRNAs. The figure illustrates the cell cycle progression in embryonic stem cells (ESCs). As shown, multiple key regulatory elements including cyclins, CDKs and CDK inhibitors are forming a network that progress cells through the four different phases of cell cycle. Several miRNA clusters and single miRNAs are involved in the regulation of cell
Cell Cycle Regulation of Stem Cells by MicroRNAs Biology Diagrams
The regulation of stem cell self-renewal must balance the regenerative needs of tissues that persist throughout life with the potential for cell overgrowth, transformation and cancer.
Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our curre โฆ 2. Cell Cycle Regulation in Pluripotent Stem Cells (PSCs) The mitotic cell division is the most fundamental process for all cell types. It is tightly regulated by the activation and deactivation of cyclin-dependent kinases (CDK) and the oscillatory expression of cyclins at different stages of the cell cycle. The canonical cell cycle in somatic cells consists of a DNA synthesis phase (S phase
